Oral and topical boswellic acid attenuates mouse osteoarthritis

Oral and topical boswellic acid attenuates mouse osteoarthritis.

OBJECTIVE Boswellic acid is a plant-derived molecule with putative anti-inflammatory effects. This study was performed to determine whether oral or topical administration of boswellic acid can attenuate joint damage in a mouse model of osteoarthritis (OA). METHODS Levels of boswellic acid were measured in the blood and synovium of mice treated with oral or topical boswellic acid. OA was gener...

Comparison between Topical and Oral Tranexamic Acid in Management of Traumatic Hyphema

Background: We sought to determine the efficacy of topical tranexamic acid (5%) in the management of traumatic hyphema.Methods: Thirty eyes with gross traumatic hyphema were enrolled in this study. The patients were treated with tranexamic acid (5%) eye drop every 6 hours for 5 days. The main outcome measures were best corrected visual acuity (BCVA), Intra-ocular pressure (IOP), day of clot abs...

11α-Ethoxy-β-boswellic acid and nizwanone, a new boswellic acid derivative and a new triterpene, respectively, from Boswellia sacra.

A new boswellic acid derivative, 11α-ethoxy-β-boswellic acid (EBA; 1) and a new ursane-type triterpene, named nizwanone (2), were isolated from Omani frankincense Boswellia sacra Flueck. together with two known compounds papyriogenin B and rigidenol. The structures of 1 and 2 were elucidated by detailed spectroscopic analysis using (1) H- and (13) C-NMR, (1) H,(1) H-COSY, HMQC, HMBC, and HR-EI-...

Pharmacokinetic study of 11-Keto -Boswellic Acid

Introduction: Boswellia serrata has been used in traditional medicine for treatment of inflammatory diseases since antiquity. However human kinetic studies are lacking for this. Hence to better elucidate its effects in humans and determine its optimal dosing, this study was planned. Material and Methods: Twelve healthy adult men volunteers were given capsule Wok Vel™ containing 333 mg of Boswel...

Topical and Regional Treatment for Osteoarthritis